Incidence of ER Negative Receptors in the Guyanese Breast Cancer Population and its Influence in Treatment Outcome

Título: Incidence of ER Negative Receptors in the Guyanese Breast Cancer Population and its Influence in Treatment Outcome

Aluno: Latoya Shonell Gooding

Local: Auditório do NPO

Data: 29/09/2018

Horário: 10h

Resumo:

In the Guyana, cancer is the third leading cause of mortality, with Breast cancer being the leading cause of cancer but the second cause of cancer death among women.

Immunohistochemistry testing is not available in Guyana, for which the ER, PR and HER2 status of the breast cancer patients are unknown, resulting in no molecular classification and patients receiving hormonal therapy for five (5) years without knowing if they require such treatment. The main objective of this study is to identify the ER, PR and HER2 status of the breast cancer population in Guyana over a five (5) years period (January 2013 to January 2018) and identify its prevalence by age, ethnicity and type of breast cancer, thus, resulting in the molecular classification of these patients. It will then compare the prevalence of the ER, PR and HER2 receptors by age, ethnicity and type of breast cancer to that of the Brazil Breast cancer population. This study is a retrospective cross sectional study that will observe the prevalence of these receptors (ER, PR and HER2) in the breast cancer population during the period January 2013 to January 2018 of all breast cancer cases diagnosed and treated at the national referring hospital, Georgetown Public Hospital Corporation (GPHC), once consent is granted from the patient or relative of the deceased breast cancer patient and their block sample is located in the pathology laboratory of the GPHC Pathology Department. The minimal of two hundred (200) cases are required to conduct this study with a duration of ten (10) months to complete the testing and analyzing of the data. This study will be first of its kind in Guyana and will serve as data to guide the treatment guidelines for breast cancer care. In the statistical analysis of cancers in Guyana by Dr. Morris Edwards in 2015, where it analyzed cancers in Guyana during 2003 – 2012, it highlighted the vast lack of effective care cancer in our country, while it recorded a total of six thousand five hundred and eighteen (6518) cases of cancer, with 56% of the total cases received no treatment and 44% received treatment ranging from surgery, chemotherapy, radiotherapy and hormonal therapy. (Edwards 2015) In my observation, hormonal therapy became very popular in Guyana from 2013, where all diagnosed breast cancer patients started receiving such after their chemotherapy and radiotherapy is completed, for duration of five (5) years without having their immunohistochemistry test done to determine their ER/PR status. Recorded breast cancer cases were one thousand and ninety (1090) cases with, with one thousand and seventy four (1074) cases in females and sixteen (16) in males. It observed that breast cancer was prevalent in older women, peaking highest in age 70 – 74 and a high predominance for the Indo Guyanese breast cancer population.

Banca Examinadora: